Important
Important
It is possible that the main title of the report Tooth and Nail Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
Synonyms
- Dysplasia of Nails With Hypodontia
- Nail Dysgenesis and Hypodontia
Disorder Subdivisions
- None
General Discussion
Tooth and Nail syndrome is a rare genetic disorder that belongs to a group of diseases known as ectodermal dysplasia. Ectodermal dysplasia typically affect the teeth, nails, hair, and/or skin. Tooth and Nail syndrome is characterized by absence (hypodontia) and/or malformation of certain primary (deciduous) and secondary (permanent) teeth occurring in association with improper development (dysplasia) of the nails, particularly the toenails.
In individuals with Tooth and Nail syndrome, certain primary teeth and/or several secondary teeth may either be absent or widely spaced and/or conical in shape (coniform). In addition, in infants with the disorder, certain nails may be absent at birth and may grow extremely slowly, particularly during the first two to three years of life. The nails may be unusually small and underdeveloped (hypoplastic), with distinctive, abnormal hollowing that causes them to appear spoon shaped. The toenails are usually more severely affected than the fingernails. In rare cases, additional symptoms and findings are present. Tooth and Nail Syndrome is inherited as an autosomal dominant genetic trait.
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Resources
National Foundation for Ectodermal Dysplasias
410 East Main Street
PO Box 114
Mascoutah, IL 62258-0114
Tel: (618)566-2020
Fax: (618)566-4718
Email: info@nfed.org
Internet: http://www.nfed.org
NIH/National Institute of Dental and Craniofacial Research
Tel: (301)496-4261
Fax: (301)496-9988
Email: nidcr@nih.gov
Internet: http://www.nidcr.nih.gov/
NIH/National Oral Health Information Clearinghouse
1 NOHIC Way
Bethesda, MD 20892-3500
USA
Tel: 3014027364
Fax: 3019078830
TDD: 3016567581
Email: nohic@nidcr.nih.gov
Internet: http://www.nohic.nidcr.nih.gov
